Different phospholipase-C-coupled receptors differentially regulate capacitative and non-capacitative Ca2+ entry in A7r5 cells.

@article{Moneer2005DifferentPR,
  title={Different phospholipase-C-coupled receptors differentially regulate capacitative and non-capacitative Ca2+ entry in A7r5 cells.},
  author={Zahid Moneer and Irene Pino and Emily J. A. Taylor and Lisa M. Broad and Yingjie Liu and Stephen C. Tovey and Leila Staali and Colin W Taylor},
  journal={The Biochemical journal},
  year={2005},
  volume={389 Pt 3},
  pages={821-9}
}
Several receptors, including those for AVP (Arg8-vasopressin) and 5-HT (5-hydroxytryptamine), share an ability to stimulate PLC (phospholipase C) and so production of IP3 (inositol 1,4,5-trisphosphate) and DAG (diacylglycerol) in A7r5 vascular smooth muscle cells. Our previous analysis of the effects of AVP on Ca2+ entry [Moneer, Dyer and Taylor (2003) Biochem. J. 370, 439-448] showed that arachidonic acid released from DAG stimulated NO synthase. NO then stimulated an NCCE (non-capacitative… CONTINUE READING

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