Different pharmacological properties of two enantiomers in a unique beta-blocker, nebivolol.

@article{Ignarro2008DifferentPP,
  title={Different pharmacological properties of two enantiomers in a unique beta-blocker, nebivolol.},
  author={Louis Joseph Ignarro},
  journal={Cardiovascular therapeutics},
  year={2008},
  volume={26 2},
  pages={115-34}
}
Nebivolol is a racemic combination of d-nebivolol (+SRRR nebivolol) and l-nebivolol (-RSSS nebivolol) that differs chemically from other beta-blockers, with an absolutely symmetrical configuration developing from a central nitrogen atom. D-nebivolol and l-nebivolol divaricate pharmacologically and therapeutically, with a noticeably different profile from that of conventional beta-blockers; for instance, the selective blocking of beta(1)-adrenoceptors is determined almost exclusively by d… CONTINUE READING