Different patterns of expansion, contraction and memory differentiation of HIV-1 Gag-specific CD8 T cells elicited by adenovirus type 5 and modified vaccinia Ankara vaccines.

@article{Pillai2011DifferentPO,
  title={Different patterns of expansion, contraction and memory differentiation of HIV-1 Gag-specific CD8 T cells elicited by adenovirus type 5 and modified vaccinia Ankara vaccines.},
  author={Vinod Kumar Bhaskara Pillai and Sunil Kannanganat and Pablo Penaloza-MacMaster and Lakshmi S Chennareddi and Harriet L Robinson and Jerry Blackwell and Rama Rao Amara},
  journal={Vaccine},
  year={2011},
  volume={29 33},
  pages={5399-406}
}
The magnitude and functional quality of antiviral CD8 T cell responses are critical for the efficacy of T cell based vaccines. Here, we investigate the influence of two popular viral vectors, adenovirus type 5 (Ad5) and modified vaccinia Ankara (MVA), on expansion, contraction and memory differentiation of HIV-1 Gag insert-specific CD8 T cell responses following immunization and show different patterns for the two recombinant viral vectors. The Ad5 vector primed 6-fold higher levels of insert… CONTINUE READING

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