Different patterns of brain activation in normal aging and Alzheimer's disease from cognitional sight: meta analysis using activation likelihood estimation

@article{SadighEteghad2014DifferentPO,
  title={Different patterns of brain activation in normal aging and Alzheimer's disease from cognitional sight: meta analysis using activation likelihood estimation},
  author={S. Sadigh-Eteghad and Alireza Majdi and Mehdi Farhoudi and Mahnaz Talebi and Javad Mahmoudi},
  journal={Journal of the Neurological Sciences},
  year={2014},
  volume={343},
  pages={159-166}
}
Alzheimer disease (AD) is a chronic neurological disease, frequently affecting cognitional functions. Recently, a large body of neuro-imaging studies have aimed at finding reliable biomarkers of AD for early diagnosis of disease in contrast with healthy elderlies. We intended to have a meta-analytical study on recent functional neuroimaging studies to find the relationship between cognition in AD patients and normal elderlies. A systematic search was conducted to collect functional neuroimaging… Expand
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References

SHOWING 1-10 OF 68 REFERENCES
Functional imaging studies of episodic memory in Alzheimer's disease: a quantitative meta-analysis
TLDR
This study quantitatively demonstrates that functional imaging studies show consistent, if complex, patterns of brain activation differences between patients and controls, and support the continued evaluation of functional neuroimaging for clinical use. Expand
Visuospatial perception: an emerging biomarker for Alzheimer's disease.
TLDR
The diagnostic scope of monitoring the brain activation correlates of VSP processing in AD is discussed in terms of the key advantages of utilizing VSP-related deficits in AD for early detection and longitudinal tracking of AD. Expand
Hippocampus–precuneus functional connectivity as an early sign of Alzheimer's disease: A preliminary study using structural and functional magnetic resonance imaging data
TLDR
The effect sizes of these aberrant FC levels associated with AD were greater than that of cortical atrophy levels when comparing using normalized Z score and Cohen's d measures, which indicates that an aberrantFC level may precede cortex atrophy. Expand
Voxelwise meta-analysis of gray matter anomalies in Alzheimer's disease and mild cognitive impairment using anatomic likelihood estimation
TLDR
Subtraction analysis provided evidence that the left MTL may be a neuroanatomical marker to evaluate disease progression from MCI to AD, which is consistent with the hierarchical model of neuropathological alterations of neurofibrillary tangles in AD and MCI. Expand
Relationship of fMRI activation to clinical trial memory measures in Alzheimer disease
TLDR
The relationship between functional MRI (fMRI) activation and standardized memory measures supports the potential use of fMRI to investigate regional mechanisms of treatment response in clinical trials of novel therapies for Alzheimer disease. Expand
Assessing neuronal networks: Understanding Alzheimer's disease
TLDR
Focused research efforts aimed at the integration of both function and structure hold great promise not only in improving the understanding of cognition but also of its characteristic progressive metamorphosis in complex chronic neurodegenerative disorders such as AD. Expand
Failure to modulate neural response to increased task demand in mild Alzheimer's disease: fMRI study of visuospatial processing
TLDR
Investigating the functional competency of brain regions in the visuospatial networks responsible for early clinical symptoms in AD using event-related functional magnetic resonance imaging (fMRI) confirms deficits in visUospatial abilities, and offers new insights into the neural mechanisms underlying this impairment. Expand
A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease
We reviewed case-control studies of diffusion tensor imaging (DTI) in patients with Alzheimer's dementia (AD) and mild cognitive impairment (MCI), in order to establish the relative severity andExpand
Measurement of Precuneal and Hippocampal Volumes Using Magnetic Resonance Volumetry in Alzheimer's Disease
TLDR
It is suggested that volumetric measurements of both the precuneus and hippocampus are useful radiological indices for the diagnosis of AD and the lack of correlation is attributable to local pathology rather than being a secondary consequence of MTL pathology. Expand
fMRI studies of associative encoding in young and elderly controls and mild Alzheimer’s disease
TLDR
The pattern of fMRI activation during the encoding of novel associations is differentially altered in the early stages of Alzheimer’s disease compared with normal aging. Expand
...
1
2
3
4
5
...