Different patterns of DNA methylation of the two distinct O6-methylguanine-DNA methyltransferase (O6-MGMT) promoter regions in colorectal cancer

@article{Mokarram2012DifferentPO,
  title={Different patterns of DNA methylation of the two distinct O6-methylguanine-DNA methyltransferase (O6-MGMT) promoter regions in colorectal cancer},
  author={P. Mokarram and M. Zamani and S. Kavousipour and F. Naghibalhossaini and C. Irajie and M. Moradi Sarabi and S. V. Hosseini},
  journal={Molecular Biology Reports},
  year={2012},
  volume={40},
  pages={3851-3857}
}
  • P. Mokarram, M. Zamani, +4 authors S. V. Hosseini
  • Published 2012
  • Biology, Medicine
  • Molecular Biology Reports
  • Colorectal cancer (CRC) is the third most common cancer worldwide. Colorectal cancer incidence differs widely among different geographic regions. In addition to mutational changes, epigenetic mechanisms also play important roles in the pathogenesis of CRCs. O6-methylguanine-DNA methyltransferase (O6-MGMT) is a DNA repair protein and in the absence of MGMT activity, G-to-A transition may accumulate in the specific genes such as K-ras and p53. To identify which CpG sites are critical for its… CONTINUE READING

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