Different patterns of DNA methylation of the two distinct O6-methylguanine-DNA methyltransferase (O6-MGMT) promoter regions in colorectal cancer

@article{Mokarram2012DifferentPO,
  title={Different patterns of DNA methylation of the two distinct O6-methylguanine-DNA methyltransferase (O6-MGMT) promoter regions in colorectal cancer},
  author={Pooneh Mokarram and M. Zamani and Soudabeh Kavousipour and Fakhraddin Naghibalhossaini and Cambyz Irajie and Mostafa Moradi Sarabi and Seyed Vahid Hosseini},
  journal={Molecular Biology Reports},
  year={2012},
  volume={40},
  pages={3851-3857}
}
Colorectal cancer (CRC) is the third most common cancer worldwide. Colorectal cancer incidence differs widely among different geographic regions. In addition to mutational changes, epigenetic mechanisms also play important roles in the pathogenesis of CRCs. O6-methylguanine-DNA methyltransferase (O6-MGMT) is a DNA repair protein and in the absence of MGMT activity, G-to-A transition may accumulate in the specific genes such as K-ras and p53. To identify which CpG sites are critical for its… Expand
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