Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain.

@article{Ezquerra2008DifferentPO,
  title={Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain.},
  author={L Vazquez Ezquerra and Luis F Alguacil and Trang Thi Nhu Nguyen and Thomas F. Deuel and Inmaculada Silos-santiago and Gonzalo Herrad{\'o}n},
  journal={Growth factors},
  year={2008},
  volume={26 1},
  pages={
          44-8
        }
}
Pleiotrophin (PTN) and midkine (MK) are two growth factors highly redundant in function that exhibit neurotrophic actions and are upregulated at sites of nerve injury, both properties being compatible with a potential involvement in the pathophysiological events that follow nerve damage (i.e. neuropathic pain). We have tested this hypothesis by comparatively studying PTN and MK gene expression in the spinal cord and dorsal root ganglia (DRG) of three rat strains known to differ in their… CONTINUE READING
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