Different pathways of degradation of SP-A and saturated phosphatidylcholine by alveolar macrophages.

@article{Baritussio2000DifferentPO,
  title={Different pathways of degradation of SP-A and saturated phosphatidylcholine by alveolar macrophages.},
  author={Aldo Baritussio and Avra Alberti and Decio Armanini and Floriana Meloni and Daniela Bruttomesso},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2000},
  volume={279 1},
  pages={L91-9}
}
Alveolar macrophages degrade surfactant protein (SP) A and saturated phosphatidycholine [dipalmitoylphosphatidylcholine (DPPC)]. To clarify this process, using rabbit alveolar macrophages, we analyzed the effect of drugs known to affect phagocytosis, pinocytosis, clathrin-mediated uptake, caveolae, the cytoskeleton, lysosomal pH, protein kinase C, and phosphatidylinositol 3-kinase (PI3K) on the degradation of SP-A and DPPC. We found the following: 1) SP-A binds to the plasma membrane, is… CONTINUE READING