Different pathways of apoptosis revealed by 2-chloro-adenosine and deoxy-D-ribose in mammalian astroglial cells.

@article{Ceruti1997DifferentPO,
  title={Different pathways of apoptosis revealed by 2-chloro-adenosine and deoxy-D-ribose in mammalian astroglial cells.},
  author={Stefania Ceruti and Daniela Barbieri and Elisabetta Veronese and Flaminio Cattabeni and Andrea Cossarizza and Anna Maria Giammarioli and Walter Malorni and Claudio Franceschi and Maria P. Abbracchio},
  journal={Journal of neuroscience research},
  year={1997},
  volume={47 4},
  pages={372-83}
}
Both the adenosine analogue 2-chloro-adenosine (2-CA) and the reducing sugar deoxy-D-ribose (dRib) induce apoptosis of astroglial cells in rat brain primary cultures (Abbracchio et al.: Biochem Biophys Res Commun 213:908-915, 1995). The present study was undertaken to elucidate by both morphological and cytofluorimetric analyses the intracellular mechanism(s) involved in induction of apoptosis by these two agents. The poly(ADP-ribose)polymerase (PARP) inhibitor 3-aminobenzamide did not prevent… CONTINUE READING