Different pathways leading to cutaneous leukocytoclastic vasculitis in mice.

@article{Sunderktter2001DifferentPL,
  title={Different pathways leading to cutaneous leukocytoclastic vasculitis in mice.},
  author={Cord H Sunderk{\"o}tter and Stephan Seeliger and Frank Sch{\"o}nlau and Johannes Roth and Rupert Hallmann and Thomas Anton Luger and Clemens Sorg and Gerhard Kolde},
  journal={Experimental dermatology},
  year={2001},
  volume={10 6},
  pages={391-404}
}
To investigate the pathomechanisms of leukocytoclastic vasculitis (LcV) we compared mouse models of LcV with non-vasculitic irritant contact dermatitis (ICD). Criteria for LcV as met by the immune complex-mediated Arthus reaction (Art-r) were also fulfilled by the localized Shwartzman reaction (Shw-r) and by cutaneous Loxoscelism (Lox) (injection of venom from Loxosceles reclusa containing sphingomyelinase D). After depletion of PMN (by gamma-irradiation) vessel damage could not be elicited in… CONTINUE READING