Different pathways for sodium entry in cardiac cells during ischemia and early reperfusion

@article{Baetz2003DifferentPF,
  title={Different pathways for sodium entry in cardiac cells during ischemia and early reperfusion},
  author={Delphine Baetz and Monique Bernard and Caroline Pinet and Sophie Tamareille and Soad Chattou and Houda El Banani and Alain Coulombe and Danielle Feuvray},
  journal={Molecular and Cellular Biochemistry},
  year={2003},
  volume={242},
  pages={115-120}
}
A number of data are consistent with the hypothesis that increases in intracellular Na+ concentration (Na+ i) during ischemia and early reperfusion lead to calcium overload and exacerbation of myocardial injury. However, the mechanisms underlying the increased Na+ i remain unclear. 23Na nuclear magnetic resonance spectroscopy was used to monitor Na+ i in isolated rat hearts perfused with a high concentration of fatty acid as can occur under some pathological conditions. Whole-cell patch-clamp… CONTINUE READING

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