Different neurotransmitter systems are involved in the development of esophageal achalasia.

@article{Sigala1995DifferentNS,
  title={Different neurotransmitter systems are involved in the development of esophageal achalasia.},
  author={Sandra Sigala and Guido Missale and Cristina Missale and Vincenzo Villanacci and Rossella Cestari and Pier Giovanni Grigolato and L Lojacono and Pier Franco Spano},
  journal={Life sciences},
  year={1995},
  volume={56 16},
  pages={1311-20}
}
Clinical and pharmacological evidence suggests that several neurotransmitters are involved in the control of the esophageal motility; in fact, besides the well known cholinergic and sympathetic innervation, Vasoactive Intestinal Polypeptide (VIP)-containing fibers as well as dopamine (DA)-containing nerve endings have been identified within the esophageal wall. Lower Esophageal Sphincter (LES) achalasia is a neuromuscular disorder characterized by the absence of peristalsis in the body of the… CONTINUE READING

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