Different molecular targets of Icariin on bMSCs in CORT and OVX -rats.

@article{Bian2012DifferentMT,
  title={Different molecular targets of Icariin on bMSCs in CORT and OVX -rats.},
  author={Q. Bian and Jian-hua Huang and Shu-fen Liu and Y. Ning and Zhu Yang and Yong-Jian Zhao and Zi-yin Shen and Yong-jun Wang},
  journal={Frontiers in bioscience},
  year={2012},
  volume={4},
  pages={
          1224-36
        }
}
Icariin (ICA) is an active component of Herba Epimedium effective in preventing osteoporosis. Bone mesenchymal stem cells (bMSCs) are an important target by which ICA promotes osteogenesis. However, its molecular mechanisms are poorly defined. In the present study, we induced osteoporosis in rats by corticosterone (CORT) and ovariectomy (OVX), treated both with ICA for 2 weeks or 3 months. As results, both models displayed bone loss tendency within 2 weeks and a significant bone loss after 3… Expand
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