Different molecular mechanisms are involved in the multihormonal control of glucose transport in FRTL5 rat thyroid cells.

@article{Russo1994DifferentMM,
  title={Different molecular mechanisms are involved in the multihormonal control of glucose transport in FRTL5 rat thyroid cells.},
  author={Diego Russo and Giuseppe Damante and Daniela P Foti and Giuseppe Costante and Sebastiano Filetti},
  journal={Journal of endocrinological investigation},
  year={1994},
  volume={17 5},
  pages={323-7}
}
We investigated the molecular mechanisms by which TSH, insulin and IGF-1 modulate the glucose transport system in FRTL5 cells. We found that TSH, insulin and IGF-1 increased the glucose transporter Glut-1 specific mRNA levels 6, 8 and 5 fold over control, respectively. The effect on Glut-1 mRNA was evident after 2 hours, followed by an increased Glut-1 protein expression in whole cells, as judged by western blot analysis, after 5 hours of stimulation with all the hormones studied. In contrast… CONTINUE READING

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