Different molecular forms of cholecystokinin and CCKB receptor binding in the rat brain after chronic antidepressant treatment

@article{Harro1996DifferentMF,
  title={Different molecular forms of cholecystokinin and CCKB receptor binding in the rat brain after chronic antidepressant treatment},
  author={Jaanus Harro and Charlotta L{\"o}fberg and Rein P{\"a}hkla and Vallo Matto and Lembit R{\"a}go and Lars Oreland and Lembit Allikmets},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1996},
  volume={355},
  pages={57-63}
}
Cholecystokinin (CCK) is a neuropeptide recently implicated in affective disorders. This study aimed at measuring the levels of different molecular forms of CCK and the binding characteristics of CCKB receptors in the rat brain after three weeks of treatment with four different antidepressants, imipramine, amitriptyline, desipramine, and citalopram (all at the dose of 10 mg/kg once per day i.p.). Chronic treatment with imipramine and desipramine had a significant immobility-reducing effect in… CONTINUE READING

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