Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells.

@article{Vaculov2006DifferentMO,
  title={Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells.},
  author={Alena Hyr{\vs}lov{\'a} Vaculov{\'a} and Jiřina Hofmanov{\'a} and Karel Sou{\vc}ek and Alois Kozub{\'i}k},
  journal={FEBS letters},
  year={2006},
  volume={580 28-29},
  pages={6565-9}
}
Epithelial cells can be manipulated to undergo apoptosis depending on the balance between pro-survival and apoptotic signals. We showed that TRAIL-induced apoptosis may be differentially regulated by inhibitors of MEK ERK (U0126) or PI3K/Akt (LY294002) pathway in TRAIL-sensitive (HT-29) and TRAIL-resistant (SW620) human epithelial colon cancer cells. U0126 or LY294002 significantly enhanced TRAIL-induced apoptosis in HT-29 cells, but not in SW620 cells. We report a different regulation of the… CONTINUE READING

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