Different modes of stop codon restriction by the Stylonychia and Paramecium eRF1 translation termination factors.

@article{Lekomtsev2007DifferentMO,
  title={Different modes of stop codon restriction by the Stylonychia and Paramecium eRF1 translation termination factors.},
  author={Sergey Lekomtsev and Petr M. Kolosov and Laure Bidou and Ludmila Frolova and Jean-Pierre Rousset and L. Kisselev},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 26},
  pages={10824-9}
}
In universal-code eukaryotes, a single-translation termination factor, eukaryote class-1 polypeptide release factor (eRF1), decodes the three stop codons: UAA, UAG, and UGA. In some ciliates, like Stylonychia and Paramecium, eRF1s exhibit UGA-only decoding specificity, whereas UAG and UAA are reassigned as sense codons. Because variant-code ciliates may have evolved from universal-code ancestor(s), structural features should exist in ciliate eRF1s that restrict their stop codon recognition. In… CONTINUE READING