Different modes of herpes simplex virus type 1 spread in brain and skin tissues

@article{Tsalenchuck2013DifferentMO,
  title={Different modes of herpes simplex virus type 1 spread in brain and skin tissues},
  author={Yael Tsalenchuck and Tomer Tzur and Israel Steiner and Amos Panet},
  journal={Journal of NeuroVirology},
  year={2013},
  volume={20},
  pages={18-27}
}
Herpes simplex virus type 1 (HSV-1) initially infects the skin and subsequently spreads to the nervous system. To investigate and compare HSV-1 mode of propagation in the two clinically relevant tissues, we have established ex vivo infection models, using native tissues of mouse and human skin, as well as mouse brain, maintained in organ cultures. HSV-1, which is naturally restricted to the human, infects and spreads in the mouse and human skin tissues in a similar fashion, thus validating the… CONTINUE READING
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