Different modes of cell death induced by 5-fluoro-2'-deoxyuridine in two clones of the mouse mammary tumor FM3A cell line.

@article{Kakutani1998DifferentMO,
  title={Different modes of cell death induced by 5-fluoro-2'-deoxyuridine in two clones of the mouse mammary tumor FM3A cell line.},
  author={Toshiyuki Kakutani and Yumiko Ebara and K Kanja and Masumi Hidaka and Yoshihisa Matsumoto and Akira Nagano and Yusuke Wataya},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={247 3},
  pages={773-9}
}
The mode of cell death induced by 1 microM 5-fluoro-2'-deoxyuridine (FdUrd) changed in a wild-type F28-7 clone of mouse mammary tumor FM3A cells after a six-month culture. In the original stocked F28-7 clone, FdUrd-induced cell death was accompanied by necrosis-like cell swelling and DNA fragmentation to 100-200 kbp. In subclone F28-7-A isolated from F28-7 cells, which had been cultured for six months, apoptotic bodies and nucleosomal DNA-ladder fragments were observed with the treatment… CONTINUE READING