Different migration patterns of antigen-presenting cells correlate with Th1/Th2-type responses in mice.

@article{Morikawa1995DifferentMP,
  title={Different migration patterns of antigen-presenting cells correlate with Th1/Th2-type responses in mice.},
  author={Yoshihiro Morikawa and Kazuo Tohya and Hitoshi Ishida and Nami Matsuura and Kennichi Kakudo},
  journal={Immunology},
  year={1995},
  volume={85 4},
  pages={
          575-81
        }
}
Antibodies are produced when antigen-presenting cells (APC) pulsed with an antigen are injected intravenously (i.v.) into BALB/c mice, but subcutaneous (s.c.) injection of such APC causes delayed-type hypersensitivity (DTH). To identify the anatomic sites where T and B cells are activated, we labelled splenic dendritic cells (DC) with a fluorochrome, PKH 26, injected them i.v. or s.c., and used the label to locate them. When the DC were injected i.v., germinal centres in the spleen were… CONTINUE READING
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