Different methylation and microRNA expression pattern in male and female familial breast cancer.

  title={Different methylation and microRNA expression pattern in male and female familial breast cancer.},
  author={Rosamaria Pinto and Brunella Pilato and Laura Ottini and Rossana Lambo and Giovanni Simone and Angelo Virgilio Paradiso and Stefania Tommasi},
  journal={Journal of cellular physiology},
  volume={228 6},
Epigenetic regulation, has been very scarcely explored in familial breast cancer (BC). In the present study RASSF1A and RAR beta promoter methylation and miR17, miR21, miR 124, and let-7a expression were investigated to highlight possible differences of epigenetic regulation between male and female familial BC, also in comparison with sporadic BC. These epigenetic alterations were studied in 56 familial BC patients (27 males and 29 females) and in 16 female sporadic cases. RASSF1A resulted more… CONTINUE READING


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