Different mechanisms underlie the long-term regulation of pyruvate dehydrogenase kinase (PDHK) by tri-iodothyronine in heart and liver.

@article{Priestman1997DifferentMU,
  title={Different mechanisms underlie the long-term regulation of pyruvate dehydrogenase kinase (PDHK) by tri-iodothyronine in heart and liver.},
  author={David A. Priestman and Elizabeth Thompson Donald and Mark J. Holness and Mary C. Sugden},
  journal={FEBS letters},
  year={1997},
  volume={419 1},
  pages={55-7}
}
Antibodies to purified recombinant PDHKII were used for ELISAs of PDHKII in mitochondrial extracts. In liver, hyperthyroidism elicited a 2.3-fold increase in PDHK activity (P < 0.01) which was accompanied by a significant 1.5-fold (P < 0.001) increase in the amount of mitochondrial immunoreactive PDHKII. In contrast, despite a stable 2.0-fold increase in cardiac PDHK activity (P < 0.001), the amount of mitochondrial immunoreactive PDHKII in heart was unaffected by hyperthyroidism. The… CONTINUE READING

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