Different mechanisms regulate muscle-specific AChR gamma- and epsilon-subunit gene expression.

@article{Numberger1991DifferentMR,
  title={Different mechanisms regulate muscle-specific AChR gamma- and epsilon-subunit gene expression.},
  author={M Numberger and I D{\"u}rr and Wilfried B Kues and Michael Koenen and Veit Witzemann},
  journal={The EMBO journal},
  year={1991},
  volume={10 10},
  pages={2957-64}
}
Five different subunits, alpha, beta, gamma, delta and epsilon, constitute the acetylcholine receptors from mammalian skeletal muscle. Their corresponding mRNA levels are regulated differentially. In particular, mRNAs encoding the gamma- and epsilon-subunits, which specify two AChR isoforms, show a reciprocal behaviour during synapse formation and maturation. We have isolated 5' flanking sequences of the gamma- and epsilon-subunit genes that confer muscle-specific expression upon transient… CONTINUE READING