Different mechanisms of positive chronotropic actions of isoprenaline and noradrenaline on isolated guinea pig right atria revealed by pretreatment with rilmakalim.

Abstract

In this study we tested the influence of activation of ATP-sensitive K+ channels (KATP) on the changes in automatism induced by isoprenaline, noradrenaline and phenylephrine. Experiments were performed on the spontaneously beating right atria isolated from guinea pig. The rate of spontaneously beating preparations was measured under different experimental… (More)

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