Different locomotor sensitization responses to repeated cocaine injections are associated with differential phosphorylation of GluA1 in the dorsomedial striatum of adult rats

@article{Kim2013DifferentLS,
  title={Different locomotor sensitization responses to repeated cocaine injections are associated with differential phosphorylation of GluA1 in the dorsomedial striatum of adult rats},
  author={Myonghwan Kim and Wonju Kim and Ja-Hyun Baik and Bong-June Yoon},
  journal={Behavioural Brain Research},
  year={2013},
  volume={257},
  pages={71-76}
}
Behavioral sensitization to psychostimulants reflects neural adaptation, which might share a common mechanism with drug addiction. Outbred male rats show different locomotor sensitization responses to cocaine, and cocaine also produces varied addictive progress in humans. We investigated whether differences in the induction of sensitization would affect the long-term persistence of sensitized locomotor activity, and we sought to determine the molecular basis for the variability in sensitization… CONTINUE READING