Different levels of variability in subtypes 1b and 4a of hepatitis C viruses.

@article{Argentini2003DifferentLO,
  title={Different levels of variability in subtypes 1b and 4a of hepatitis C viruses.},
  author={Claudio Argentini and Stefano Dettori and Umbertina Villano and Mario Angelico and Maria Rapicetta},
  journal={Journal of biological regulators and homeostatic agents},
  year={2003},
  volume={17 2},
  pages={147-52}
}
We performed genetic and phenic analyses to evaluate nucleotide and amino-acid sequences of the amino-terminus of the E1 protein of HCV genotype 1b (extracted from databank) and 4a (characterised in this study). The non-synonymous (ka) mutation analysis demonstrated that the genome of genotype 1b was not saturated by variations, with a rate of transition/transversion (s/v) of 1.5, which is similar to the expected ratio (i.e., 2.0). The s/v ratio in genotype 4a isolates was lower (0.98… CONTINUE READING