Different levels of the neuronal nitric oxide synthase isoform modulate the rate of osteoclastic differentiation of TIB-71 and CRL-2278 RAW 264.7 murine cell clones.

@article{Nicolin2005DifferentLO,
  title={Different levels of the neuronal nitric oxide synthase isoform modulate the rate of osteoclastic differentiation of TIB-71 and CRL-2278 RAW 264.7 murine cell clones.},
  author={Vanessa Nicolin and Cristina Ponti and Paola Narducci and Vittorio Grill and Roberta Bortul and Marina Zweyer and Mauro Vaccarezza and Giorgio Zauli},
  journal={The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology},
  year={2005},
  volume={286 2},
  pages={945-54}
}
It has been clearly established that osteoclasts, which play a crucial role in bone resorption, differentiate from hematopoietic cells belonging to the monocyte/macrophage lineage in the presence of macrophage-colony stimulating factor (M-CSF) and receptor activator of NF-kappaB ligand (RANKL). We have here investigated the M-CSF- and RANKL-induced… CONTINUE READING