Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.

@article{Domalik1991DifferentIO,
  title={Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.},
  author={L J Domalik and David D. Chaplin and Marian Sue Kirkman and Roy Chen-Chih Wu and Wei Liu and Thad A. Howard and Michael F. Seldin and Keith L. Parker},
  journal={Molecular endocrinology},
  year={1991},
  volume={5 12},
  pages={1853-61}
}
We have isolated and characterized two isozymes of mouse steroid 11 beta-hydroxylase (11 beta-OHase), designated 11 beta-OHase and aldosterone synthase (AS). Physical mapping of overlapping cosmid and phage isolates defined two genes (designated Cyp11b-1 and Cyp11b-2 in the standard nomenclature for cytochrome P450 genes) that are oriented in the same direction and separated by approximately 8 kilobase pairs of DNA. The two genes are highly homologous in their coding regions, with 84… CONTINUE READING

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