Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes.

@article{Galeotti2008DifferentIO,
  title={Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes.},
  author={N. Galeotti and A. Quattrone and E. Vivoli and M. Norcini and A. Bartolini and C. Ghelardini},
  journal={Learning \& memory},
  year={2008},
  volume={15 5},
  pages={
          315-23
        }
}
The administration of the ryanodine receptor (RyR) agonist 4-Cmc (0.003-9 nmol per mouse intracerebroventricularly [i.c.v.]) ameliorated memory functions, whereas the RyR antagonist ryanodine (0.0001-1 nmol per mouse i.c.v.) induced amnesia in the mouse passive avoidance test. The role of the type 1, 2, and 3 RyR isoforms in memory processes was then evaluated by inhibiting the expression of the three RyR proteins in the mouse brain. A selective knockdown of the RyR isoforms was obtained by the… Expand
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  • J. Mackrill
  • Biology, Medicine
  • Biochemical pharmacology
  • 2010
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