Different intrinsic activities of bucindolol, carvedilol and metoprolol in human failing myocardium.

@article{Maack2000DifferentIA,
  title={Different intrinsic activities of bucindolol, carvedilol and metoprolol in human failing myocardium.},
  author={Christoph Maack and Bodo Cremers and Markus Flesch and Anje C. H{\"o}per and Michael J Suedkamp and Michael B{\"o}hm},
  journal={British journal of pharmacology},
  year={2000},
  volume={130 5},
  pages={1131-9}
}
1. Clinical studies have shown different effects of beta-blockers on the beta-adrenergic system, tolerability and outcome in patients with heart failure. 2. The study examines beta-adrenoceptor-G-protein coupling and intrinsic activity of bucindolol, carvedilol and metoprolol in human ventricular myocardium. 3. Radioligand binding studies ([(125)I]-Iodocyanopindolol) were performed in membrane preparations of human failing and nonfailing myocardium. Functional experiments were carried out in… CONTINUE READING
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