Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

@article{Shymanets2015DifferentIO,
  title={Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.},
  author={Aliaksei Shymanets and Prajwal and Oscar Vadas and Cornelia Czupalla and Jaclyn Lopiccolo and M. Brenowitz and Alessandra Ghigo and Emilio Hirsch and Eberhard Krause and Reinhard Wetzker and Roger L Williams and Christian Harteneck and B. Meinecke N{\"u}rnberg},
  journal={The Biochemical journal},
  year={2015},
  volume={469 1},
  pages={59-69}
}
Class IB phosphoinositide 3-kinases γ (PI3Kγ) are second-messenger-generating enzymes downstream of signalling cascades triggered by G-protein-coupled receptors (GPCRs). PI3Kγ variants have one catalytic p110γ subunit that can form two different heterodimers by binding to one of a pair of non-catalytic subunits, p87 or p101. Growing experimental data argue… CONTINUE READING