Different inducibility of radiation- or heat-induced p53-dependent apoptosis after acute or chronic irradiation in human cultured squamous cell carcinoma cells.

@article{Takahashi2001DifferentIO,
  title={Different inducibility of radiation- or heat-induced p53-dependent apoptosis after acute or chronic irradiation in human cultured squamous cell carcinoma cells.},
  author={Akihisa Takahashi},
  journal={International journal of radiation biology},
  year={2001},
  volume={77 2},
  pages={215-24}
}
PURPOSE This study was undertaken to clarify the effects of acute or chronic pre-irradiation on the induction of p53-dependent apoptosis by X-rays or heat shock. MATERIALS AND METHODS Having an identical genotype except for p53-status, the human cultured squamous cell carcinoma cells (SAS) were transfected with a mutant p53 gene (SAS/mp53) or neo alone (SAS/neo) as a control. After acute X-irradiation (1 Gy min(-1)), chronic gamma-irradiation (0.001 Gy min(-1)) or heat shock (44 degrees C… CONTINUE READING

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