Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

@article{Knudsen2016DifferentHV,
  title={Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens},
  author={N. P. Knudsen and A. Olsen and C. Buonsanti and Frank Follmann and Y. Zhang and R. Coler and Christopher B Fox and Andreas Meinke and Ugo D´Oro and D. Casini and A. Bonci and R. Billeskov and E. De Gregorio and R. Rappuoli and A. Harandi and P. Andersen and E. Agger},
  journal={Scientific Reports},
  year={2016},
  volume={6}
}
  • N. P. Knudsen, A. Olsen, +14 authors E. Agger
  • Published 2016
  • Biology, Medicine
  • Scientific Reports
  • The majority of vaccine candidates in clinical development are highly purified proteins and peptides relying on adjuvants to enhance and/or direct immune responses. Despite the acknowledged need for novel adjuvants, there are still very few adjuvants in licensed human vaccines. A vast number of adjuvants have been tested pre-clinically using different experimental conditions, rendering it impossible to directly compare their activity. We performed a head-to-head comparison of five different… CONTINUE READING
    128 Citations

    Figures, Tables, and Topics from this paper

    Influenza NG-34 T cell conserved epitope adjuvanted with CAF01 as a possible influenza vaccine candidate
    • 2
    • Highly Influenced
    Immunology and efficacy of MF59-adjuvanted vaccines
    • 14
    Modulation of Primary Immune Response by Different Vaccine Adjuvants
    • 37
    • PDF
    Biotechnology approaches to produce potent, self-adjuvanting antigen-adjuvant fusion protein subunit vaccines.
    • 41
    B cell targeting by molecular adjuvants for enhanced immunogenicity
    Different Adjuvants Induce Common Innate Pathways That Are Associated with Enhanced Adaptive Responses against a Model Antigen in Humans
    • W. Burny, A. Callegaro, +11 authors Viviane Wivine Andrea Isabelle Frédéric Sophie Arnaud Mera Bechtold Burny Callegaro Carletti Clement Delhaye
    • Biology, Medicine
    • Front. Immunol.
    • 2017
    • 29
    • PDF
    Adjuvants as Delivery Systems in Antigen-Specific Immunotherapies.

    References

    SHOWING 1-10 OF 77 REFERENCES
    A Synthetic Adjuvant to Enhance and Expand Immune Responses to Influenza Vaccines
    • 124
    • PDF
    Vaccine adjuvants: scientific challenges and strategic initiatives
    • 84
    Vaccine adjuvants: Current state and future trends
    • 779
    • PDF