Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens

  title={Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens},
  author={N. P. Knudsen and A. Olsen and C. Buonsanti and Frank Follmann and Y. Zhang and R. Coler and Christopher B Fox and Andreas Meinke and Ugo D´Oro and D. Casini and A. Bonci and R. Billeskov and E. De Gregorio and R. Rappuoli and A. Harandi and P. Andersen and E. Agger},
  journal={Scientific Reports},
  • N. P. Knudsen, A. Olsen, +14 authors E. Agger
  • Published 2016
  • Biology, Medicine
  • Scientific Reports
  • The majority of vaccine candidates in clinical development are highly purified proteins and peptides relying on adjuvants to enhance and/or direct immune responses. Despite the acknowledged need for novel adjuvants, there are still very few adjuvants in licensed human vaccines. A vast number of adjuvants have been tested pre-clinically using different experimental conditions, rendering it impossible to directly compare their activity. We performed a head-to-head comparison of five different… CONTINUE READING
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