Different heparan sulfate proteoglycans serve as cellular receptors for human papillomaviruses.

@article{ShaftiKeramat2003DifferentHS,
  title={Different heparan sulfate proteoglycans serve as cellular receptors for human papillomaviruses.},
  author={Saeed Shafti-Keramat and Alessandra Handisurya and Ernst Kriehuber and Guerrino Meneguzzi and Katharina Slupetzky and Reinhard Kirnbauer},
  journal={Journal of virology},
  year={2003},
  volume={77 24},
  pages={13125-35}
}
Papillomaviruses replicate in stratified epithelia of skin and mucosa. Infection with certain human papillomavirus (HPV) types is the main cause of anogenital neoplasia, in particular cervical cancer. Early events of papillomavirus infectivity are poorly understood. While heparan sulfate proteoglycans (HSPGs) mediate initial binding to the cell surface, the class of proteins carrying heparan sulfates has not been defined. Here we examined two processes of papillomavirus infection, attachment of… CONTINUE READING

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