Different functional properties of troponin T mutants that cause dilated cardiomyopathy.

@article{Venkatraman2003DifferentFP,
  title={Different functional properties of troponin T mutants that cause dilated cardiomyopathy.},
  author={Ganapathi Venkatraman and Kazuhiro Harada and Aldrin V Gomes and W. Glenn L. Kerrick and James D. Potter},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 43},
  pages={
          41670-6
        }
}
The effects of Troponin T (TnT) mutants R141W and DeltaK210, the only two currently known mutations in TnT that cause dilated cardiomyopathy(DCM) independent of familial hypertrophic cardiomyopathy (FHC), and TnT-K273E, a mutation that leads to a progression from FHC to DCM, were investigated. Studies on the Ca2+ sensitivity of force development in porcine cardiac fibers demonstrated that TnT-DeltaK210 caused a significant decrease in Ca2+ sensitivity, whereas the TnT-R141W did not result in… CONTINUE READING
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