Different frequencies of p53 codon-249 hot-spot mutations in hepatocellular carcinomas in Jiang-su province of China.

@article{Shimizu1999DifferentFO,
  title={Different frequencies of p53 codon-249 hot-spot mutations in hepatocellular carcinomas in Jiang-su province of China.},
  author={Yuki Shimizu and Junwei J Zhu and Feng Han and Takenori Ishikawa and Hiroko Oda},
  journal={International journal of cancer},
  year={1999},
  volume={82 2},
  pages={187-90}
}
Environmental carcinogens often induce specific mutations in the p53 gene, apparent in tumors. The relation between aflatoxin B1 (AFB1 )-related hepatocellular carcinomas (HCCs) and hot spot at codon 249 of the p53 gene has received a great deal of attention, but its significance is still controversial. To clarify this problem, we analyzed the p53-mutational status of HCCs in Jiang-su province in China, where AFB1 contamination of the staple food significantly differs between the northern and… CONTINUE READING

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