Different fates of Legionella pneumophila pmi and mil mutants within macrophages and alveolar epithelial cells.

@article{Gao1998DifferentFO,
  title={Different fates of Legionella pneumophila pmi and mil mutants within macrophages and alveolar epithelial cells.},
  author={L. Y. Gao and Bernell Stone and Joan K. Brieland and Yousef Abu Kwaik},
  journal={Microbial pathogenesis},
  year={1998},
  volume={25 6},
  pages={291-306}
}
Alveolar epithelial cells, which constitute the majority of the alveolar surface, may represent a potential niche for intracellular replication of Legionella pneumophila that has been largely overlooked. We examined the phenotypes of a bank of 121 macrophage-defective mutants of L. pneumophila (designated as pmi and mil) for their cytopathogenicity to and intracellular survival and replication within human alveolar epithelial cells. Our data showed that 91 of 121 mutants that were defective… CONTINUE READING

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