Different familial transmission patterns in bipolar I disorder with onset before and after age 25.

  title={Different familial transmission patterns in bipolar I disorder with onset before and after age 25.},
  author={Maria Grigoroiu-Serbanescu and M Martinez and Markus M. N{\"o}then and Mor Grinberg and Dorina Sima and P. Propping and Elvira Marinescu and M Hrestic},
  journal={American journal of medical genetics},
  volume={105 8},
Gene identification in common disorders such as Alzheimer disease and breast cancer has greatly profited from the use of age of onset as criterion to delineate subgroups of disease characterized by different inheritance patterns. In bipolar affective disorder, where the majority of linkage studies have produced conflicting results, studies reporting clinical characteristics and familial occurrence of disease have suggested that age of onset might serve as an indicator for identifying more… CONTINUE READING


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