Different expression of glycogen synthase kinase-3beta between young and old rat brains after transient middle cerebral artery occlusion.

@article{Sasaki2001DifferentEO,
  title={Different expression of glycogen synthase kinase-3beta between young and old rat brains after transient middle cerebral artery occlusion.},
  author={Chihoko Sasaki and Takeshi Hayashi and Wenri Zhang and Hitoshi Warita and Yasuhiro Manabe and Kazuhisa Sakai and Koji Abe},
  journal={Neurological research},
  year={2001},
  volume={23 6},
  pages={588-92}
}
Ischemia is a common stress to human brain and is difficult to cure in older individuals. To examine the differences of the response to cerebral ischemia between young and old rat brains, distributions of glycogen synthase kinase-3beta (GSK3beta) and tau proteins were analyzed after 90 min of transient middle cerebral artery occlusion (MCAO) in young (10-11 weeks) and old (15 months) rats by immunohistochemical analyses. At 4 h of reperfusion, strong cytoplasmic and nuclear immunoreactivity for… CONTINUE READING