Different expression of caspase‐3 in rat hippocampal subregions during postnatal development

@article{Liu2008DifferentEO,
  title={Different expression of caspase‐3 in rat hippocampal subregions during postnatal development},
  author={Jinping Liu and Liansheng Chang and Xiulai Gao and Yan Wu},
  journal={Microscopy Research and Technique},
  year={2008},
  volume={71}
}
Recent studies indicate that caspase-3 has distinct characteristics in postmitotic and neuronal progenitor apoptosis. [] Key Method We used immunofluorescent staining for two isoforms of caspase-3 (an active 17 kDa isoform and an inactive 35 kDa precursor) and the Hoechst 33342 staining for nuclear chromatin to assess caspase-3 expression in the CA1, CA3, and DG of rat hippocampus during postnatal development. The expression of active caspase-3 reached a peak at P7 in CA1, at P2 in CA3, and then decreased…
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Results showed that this model of neonatal anoxia promotes cell death in CA1 and CA2-3, and different types of neuronal death in subregions of the hippocampus of rats 24 hours after anoxIA, leading to the volume increase in P14 in the CA1 region, returning to its original size and then, despite do not alter cell proliferation pattern in subgranular zone of studied ages.
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References

SHOWING 1-10 OF 32 REFERENCES
Apoptosis in the rat basal forebrain during development and following lesions of connections
TLDR
It is suggested that apoptosis is temporally coordinated with the morphological and neurochemical differentiation of BF neurons and the establishment of connections with their target areas; and cortical ablations do not affect the survival ofBF neurons, but they influence the phenotype of cholinergic BF neurons.
Key apoptosis regulating proteins are down-regulated during postnatal tissue development.
TLDR
This study shows that a selection of post-mitotic tissues down-regulate key apoptotic proteins, in contrast to the thymus, which requires apoptosis for normal function in early adulthood.
Expression of bcl-2, bax, and caspase-3 in the brain of the developing rat.
Qualitative and quantitative estimates of apoptosis from birth to senescence in the rat brain
TLDR
Assays of rat brainstem, neocortex, hippocampus, and cerebellum from birth through senescence provide a temporal and regional baseline for further studies of the effects of perturbations of cell death during neural development and quantitative and qualitative changes in these regional profiles of apoptosis due to environmental insults during early ontogeny are demonstrated.
Knock‐down of POSH expression is neuroprotective through down‐regulating activation of the MLK3–MKK4–JNK pathway following cerebral ischaemia in the rat hippocampal CA1 subfield
TLDR
The results suggest that POSH might serve as a scaffold mediating JNK signalling activation in the hippocampal CA1 region following cerebral ischaemia, and POSH AS‐ODNs exerts its protective effects on ischaemic injury through a mechanism of inhibition of the MLK3–MKK4–JNK signalling pathway, involving c‐Jun and caspase 3 activation.
SMAD pathway mediation of BDNF and TGFβ2 regulation of proliferation and differentiation of hippocampal granule neurons
TLDR
The results show that the regulation of hippocampal cell fate in vitro is regulated through an interplay between the actions of BDNF and TGFβ.
Upregulation of nitric oxide synthase II contributes to apoptotic cell death in the hippocampal CA3 subfield via a cytochrome c/caspase-3 signaling cascade following induction of experimental temporal lobe status epilepticus in the rat
Apoptosis and brain development.
  • K. Roth, C. D'Sa
  • Biology
    Mental retardation and developmental disabilities research reviews
  • 2001
TLDR
Reduced neuronal cell death in mice bearing mutations in key pro-apoptotic molecules resulted in increased numbers of neurons in a variety of neuronal subpopulations, however, targeted gene disruptions also demonstrated a heretofore underappreciated significance of neural precursor cell death and immature neuron death in nervous system development.
Cell death in the choroid plexus following transient forebrain global ischemia in the rat
TLDR
It is concluded that choroid plexus cell death may adversely affect the outcome of CA1 pyramidal neurons following transient forebrain global ischemia, through, e.g., a disruption of the blood‐cerebro spinal fluid barrier.
Stress and hippocampal neurogenesis
...
1
2
3
4
...