Different expression of calreticulin and immunoglobulin binding protein in Alzheimer’s disease brain

@article{Taguchi2000DifferentEO,
  title={Different expression of calreticulin and immunoglobulin binding protein in Alzheimer’s disease brain},
  author={Jun Taguchi and Akira Fujii and Yasuhiko Fujino and Yasumi Tsujioka and Mitsuo Takahashi and Yoshio Tsuboi and Ikuo Wada and Tatsuo Yamada},
  journal={Acta Neuropathologica},
  year={2000},
  volume={100},
  pages={153-160}
}
Both calreticulin (CRT) and immunoglobulin binding protein (Bip) have a role in the folding and assembly of oligomeric membrane proteins in the endoplasmic reticulum (ER). Recent studies have demonstrated the generation of β-amyloid protein (Aβ) 1–42, a key peptide for amyloid deposits, in the ER. We, therefore, examined the localization and expression of CRT, Bip and their mRNA by immunohistochemistry, Western blot, in situ hybridization and semiquantitative reverse transcription polymerase… CONTINUE READING
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