Different expression of NR2B and PSD‐95 in rat hippocampal subregions during postnatal development
@article{Chang2009DifferentEO,
title={Different expression of NR2B and PSD‐95 in rat hippocampal subregions during postnatal development},
author={Liansheng Chang and Jinping Liu and Ning Zhang and Yong-Jun Wang and Xiulai Gao and Yan Wu},
journal={Microscopy Research and Technique},
year={2009},
volume={72}
}The different expressions of NR2 and synaptic-associated proteins have been studied by protein and mRNA level with immunoblotting, in situ hybridization, or immunogold analysis. [] Key Result In CA1, NR2B expression decreased with age. It was high at birth, reached a plateau at P4, and declined gradually after P7. In CA3, NR2B expression was similar to that in CA1. But the stratum lucidum was devoid of staining. In DG, the NR2B expression retained a higher level.
27 Citations
Immunolocalization of NR1, NR2A, and PSD-95 in rat hippocampal subregions during postnatal development.
- BiologyActa histochemica
- 2012
Immunolocalization of CaMKII and NR2B in hippocampal subregions of rat during postnatal development.
- BiologyActa histochemica
- 2013
Dynamic SAP102 expression in the hippocampal subregions of rats and APP/PS1 mice of various ages
- Biology, PsychologyJournal of anatomy
- 2018
Fundamental data is provided to support the functional differences of SAP102 in different hippocampal subregions during postnatal periods and may serve as the basis for additional functional studies on SAP 102 in normal physiological conditions and different stages of AD.
Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease.
- BiologyCurrent Alzheimer research
- 2014
Important variations in the pattern of distribution of the NMDA receptors subunits and PSD-95 represent a marker in AD and by impairing the neuronal network, contribute to functional deterioration.
Investigation into the effects of prenatal alcohol exposure on postnatal spine development and expression of synaptophysin and PSD95 in rat hippocampus
- Biology, MedicineInternational Journal of Developmental Neuroscience
- 2014
Sex differences and synchronous development of steroid receptor coactivator-1 and synaptic proteins in the hippocampus of postnatal female and male C57BL/6 mice
- BiologySteroids
- 2012
Collagen XIX is expressed by interneurons and contributes to the formation of hippocampal synapses
- BiologyThe Journal of comparative neurology
- 2010
Data revealed not only reveal that collagen XIX is expressed by central neurons, but show for the first time that a nonfibrillar collagen is necessary for the formation of hippocampal synapses.
Differential Regulation of N-Methyl-D-Aspartate Receptor Subunits is an Early Event in the Actions of Soluble Amyloid-β(1-40) Oligomers on Hippocampal Neurons.
- BiologyJournal of Alzheimer's disease : JAD
- 2016
Results show that Aβ exerts complex and distinct regulatory effects on the trafficking and phosphorylation of GluN2A and Glu N2B, as well as on their localization within synaptic and non-synaptic sites.
Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors
- BiologyFront. Cell. Neurosci.
- 2017
The data indicate age-dependent effect of H2S on NMDA receptor mediated currents determined by glutamate receptor subunit composition, and enhanced functionality of GluN1/2A receptor in the presence of this gasotransmitter can enlarge synaptic efficacy and promote synaptic plasticity in adults.
Neuronal MHC Class I Molecules are Involved in Excitatory Synaptic Transmission at the Hippocampal Mossy Fiber Synapses of Marmoset Monkeys
- BiologyCellular and Molecular Neurobiology
- 2010
These findings add to previous studies on neuronal MHCI molecules by describing their expression and localization in the primate hippocampus and by implicating them in plasticity-related processes at the mossy fiber–CA3 synapses.
References
SHOWING 1-10 OF 31 REFERENCES
Different expression of caspase‐3 in rat hippocampal subregions during postnatal development
- BiologyMicroscopy research and technique
- 2008
The data indicate that there were specific spatio‐temporal patterns of expression of active and precursor caspase‐3 in the postnatally developing rat hippocampal subregions, and that the activation of caspases3 in neuronal progenitor cells of DG and that in thePostmitotic neurons of CA1 and CA3 may have distinct roles and mechanisms during postnatal development.
NMDA Receptor Heterogeneity During Postnatal Development of the Rat Brain: Differential Expression of the NR2A, NR2B, and NR2C Subunit Proteins
- BiologyJournal of neurochemistry
- 1997
A progressive increase in the heterogeneity of NMDA receptors is revealed due to the comparably late onset of NR2A and NR2C subunit expression and by the area‐specific rearrangement ofNR2B sub unit expression following birth.
A Developmental Change in NMDA Receptor-Associated Proteins at Hippocampal Synapses
- BiologyThe Journal of Neuroscience
- 2000
These studies suggest that there is a preference for complexes of NR2A/PSD-93/95 and NR2B/SAP-102 and that individual receptor-associated proteins may have specific functions that are critical to synapse development.
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
- BiologyNeuron
- 1994
Ontogeny of postsynaptic density proteins at glutamatergic synapses
- BiologyMolecular and Cellular Neuroscience
- 2005
Improved immunohistochemical detection of postsynaptically located PSD‐95/SAP90 protein family by protease section pretreatment: A study in the adult mouse brain
- BiologyThe Journal of comparative neurology
- 2000
It is concluded that antibody access and binding to the postsynaptically located PSD‐95/SAP90 protein family are hindered when conventional immunohistochemistry is adopted, and that pepsin pretreatment effectively unmasks the post Synaptic epitopes.
Ontogeny of ionotropic glutamate receptor subunit expression in the rat hippocampus.
- BiologyBrain research. Developmental brain research
- 2002
NMDA Di-Heteromeric Receptor Populations and Associated Proteins in Rat Hippocampus
- BiologyThe Journal of Neuroscience
- 2007
In rat hippocampus, NR2A and NR2B exist primarily in di-heteromeric complexes that interact similarly with PSD-95-related proteins but are associated with different protein complexes.
Selective scarcity of NMDA receptor channel subunits in the stratum lucidum (mossy fibre‐recipient layer) of the mouse hippocampal CA3 subfield
- BiologyThe European journal of neuroscience
- 1998
The selective scarcity of theseNMDA receptor subunits in the stratum lucidum suggests that a different synaptic targeting mechanism exerts within a single CA3 pyramidal neurone in vivo, which would explain contrasting significance of the NMDA receptor channel in LTP induction mechanisms between the mossy fibre‐CA3 synapse and other hippocampal synapses.
Development of Synaptic Responses and Plasticity at the SC-CA1 and MF-CA3 Synapses in Rat Hippocampus
- BiologyCellular and Molecular Neurobiology
- 2004
The amplitudes of the fEPSP and LTP increased with age in both regions, but peaked at P30 in CA3 while they were still increasing at the oldest age studied (P60) in CA1.