Different efflux rates may determine the cellular accumulation of various bis(guanylhydrazones).

@article{AlhonenHongisto1984DifferentER,
  title={Different efflux rates may determine the cellular accumulation of various bis(guanylhydrazones).},
  author={L Alhonen-Hongisto and Richard Fagerstr{\"o}m and Romuald Laine and Hannu Elo and Juhani E J{\"a}nne},
  journal={The Biochemical journal},
  year={1984},
  volume={221 1},
  pages={273-6}
}
Three bis(guanylhydrazones) (those of methylglyoxal, glyoxal and ethylglyoxal) were compared for their affinity for the putative polyamine carrier and for their cellular retention in L1210 mouse leukaemia cells. All the bis(guanylhydrazones) inhibited equally effectively the uptake of spermidine by the tumour cells, indicating that the compounds had roughly equal affinity for the polyamine carrier. The fact that methylglyoxal bis(guanylhydrazone) and glyoxal bis(guanylhydrazone) were much more… CONTINUE READING