Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice

@inproceedings{Mitton2014DifferentEO,
  title={Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice},
  author={Kenneth P. Mitton and A. Elizabeth de Guzman and Mrinalini Deshpande and David Byrd and Camryn DeLooff and Kristina Mkoyan and Paul Zlojutro and Adrianne Wallace and Brandon M Metcalf and Kirsten Laux and Jason Sotzen and Trung Tran},
  booktitle={Molecular vision},
  year={2014}
}
PURPOSE The histone-deacetylase inhibitor activity of valproic acid (VPA) was discovered after VPA's adoption as an anticonvulsant. This generated speculation for VPA's potential to increase the expression of neuroprotective genes. Clinical trials for retinitis pigmentosa (RP) are currently active, testing VPA's potential to reduce photoreceptor loss; however, we lack information regarding the effects of VPA on available mammalian models of retinal degeneration, nor do we know if retinal gene… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in Molecular Vision

  • HL Feng, Y Leng, CH Ma, J Zhang, M Ren, DM. Chuang
  • Neuroscience
  • 2014
1 Excerpt

Similar Papers

Loading similar papers…