Different effects of thrombin receptor activation on endothelium and smooth muscle cells of human coronary bypass vessels. Implications for venous bypass graft failure.

@article{Yang1997DifferentEO,
  title={Different effects of thrombin receptor activation on endothelium and smooth muscle cells of human coronary bypass vessels. Implications for venous bypass graft failure.},
  author={Zhihong Yang and Frank T. Ruschitzka and Ton J Rabelink and Georg Noll and Friedgard Julmy and Hana Joch and Verena Gafner and Ivan Aleksi{\'c} and Ulrich Althaus and Thomas Felix L{\"u}scher},
  journal={Circulation},
  year={1997},
  volume={95 7},
  pages={1870-6}
}
BACKGROUND Thrombin is implicated in coronary bypass graft disease; it cleaves its receptor's extracellular N-terminal domain and unmasks a new N-terminus as a tethered ligand. We studied the effects of thrombin receptor activation in human internal mammary artery (IMA) and saphenous vein (SV). METHODS AND RESULTS To study the effects of thrombin receptor activation on vasomotion, isolated blood vessels were suspended for isometric tension recording, and the effects on cell proliferation were… CONTINUE READING

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