Different effects of the selective serotonin reuptake inhibitors fluvoxamine, paroxetine, and sertraline on the pharmacokinetics of fexofenadine in healthy volunteers.

@article{Saruwatari2012DifferentEO,
  title={Different effects of the selective serotonin reuptake inhibitors fluvoxamine, paroxetine, and sertraline on the pharmacokinetics of fexofenadine in healthy volunteers.},
  author={Junji Saruwatari and norio Yasui-Furukori and Takenori Niioka and Yumiko Akamine and Ayaka Takashima and Sunao Kaneko and Tsukasa Uno},
  journal={Journal of clinical psychopharmacology},
  year={2012},
  volume={32 2},
  pages={
          195-9
        }
}
Although the interaction between selective serotonin reuptake inhibitors (SSRIs) and other drugs is important in the treatment of depression, there have been few studies of SSRIs concerning transporter-mediated interactions in humans. The objective of this study was to evaluate the in vivo effects of commonly used SSRIs on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate.Twelve healthy volunteers (3 females and 9 males) were enrolled in this study. Each subject received a 60-mg… CONTINUE READING
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