Different effects of proton pump inhibitors and famotidine on the clopidogrel metabolic activation by recombinant CYP2B6, CYP2C19 and CYP3A4.

@article{Ohbuchi2012DifferentEO,
  title={Different effects of proton pump inhibitors and famotidine on the clopidogrel metabolic activation by recombinant CYP2B6, CYP2C19 and CYP3A4.},
  author={Masato Ohbuchi and Kiyoshi Noguchi and Akio Kawamura and Takashi Usui},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2012},
  volume={42 7},
  pages={633-40}
}
Inhibitory potential of proton pump inhibitors (PPIs) and famotidine, an H(2) receptor antagonist, on the metabolic activation of clopidogrel was evaluated using recombinant CYP2B6, CYP2C19 and CYP3A4. Formation of the active metabolite from an intermediate metabolite, 2-oxo-clopidogrel, was investigated by liquid chromatography-tandem mass spectrometry and three peaks corresponding to the pharmacologically active metabolite and its stereoisomers were detected. Omeprazole potently inhibited… CONTINUE READING