Different effects of pH on the permeation of pilocarpine and pilocarpine prodrugs across the isolated rabbit cornea.

@article{Suhonen1998DifferentEO,
  title={Different effects of pH on the permeation of pilocarpine and pilocarpine prodrugs across the isolated rabbit cornea.},
  author={Pekka Suhonen and Tomi J{\"a}rvinen and Sanna Koivisto and Arto Urtti},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={1998},
  volume={6 3},
  pages={169-76}
}
Ocular absorption of pilocarpine and many other ophthalmic drugs can be improved by prodrug derivatization. For stability and solubility reasons basic prodrugs must be formulated at acidic pH, which may affect the corneal drug permeability. We studied the effects of pH on in vitro permeation of pilocarpine, pilocarpic acid benzyl diester prodrugs [O-propionyl (I) and O-valeryl (II)] and O,O'-(1, 4-xylylene) bispilocarpic acid diester prodrugs [O,O'-diacetyl (III), O,O'-dipropionyl (IV) and O,O… CONTINUE READING