Different effects of eNOS and nNOS inhibition on transient forebrain ischemia.

  title={Different effects of eNOS and nNOS inhibition on transient forebrain ischemia.},
  author={Min Jiang and Tomohiro Kaku and Junichi Hada and Yasumasa Hayashi},
  journal={Brain research},
  volume={946 1},
To clarify the functions of nitric oxide (NO) induced by either neuronal NO synthase (nNOS) or endothelial NO synthase (eNOS) after transient cerebral ischemia, we investigated the effects of L-N(5)-(1-iminoethyl)ornithine (L-NIO), a relatively selective eNOS inhibitor, and 7-nitroindazole (7-NI), a relatively selective nNOS inhibitor, on hippocampal dysfunction caused by cerebral ischemia. We measured mean arterial blood pressure (MABP), hippocampal blood flow, direct current (DC) potential… CONTINUE READING


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