Different effects of cocaine and nomifensine on dopamine uptake in the caudate-putamen and nucleus accumbens.

@article{Jones1995DifferentEO,
  title={Different effects of cocaine and nomifensine on dopamine uptake in the caudate-putamen and nucleus accumbens.},
  author={Sara R Jones and Paul Garris and R Mark Wightman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={274 1},
  pages={396-403}
}
The effects of cocaine and nomifensine on the uptake of dopamine have been compared in the caudate-putamen and nucleus accumbens of rat brain slices. Electrical stimulation of brain slices was used to evoke dopamine efflux and the changes in dopamine concentration in the extracellular fluid were monitored with fast-scan cyclic voltammetry with Nafion-coated, carbon-fiber electrodes. The disappearance of extracellular dopamine after the stimulation fit Michaelis-Menten kinetics in both regions… CONTINUE READING

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