Different effects of chloroquine and hydroxychloroquine on lysosomal function in cultured retinal pigment epithelial cells.

@article{Sundelin2002DifferentEO,
  title={Different effects of chloroquine and hydroxychloroquine on lysosomal function in cultured retinal pigment epithelial cells.},
  author={Staffan P. Sundelin and Alexei Terman},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  year={2002},
  volume={110 6},
  pages={481-9}
}
Although relatively rare, retinopathy based on a disturbed metabolism of the retinal pigment epithelium (RPE), with ensuing degeneration of photoreceptors, is a known complication of treatment with the 4-aminoquinolones, chloroquine (CQ) and hydroxychloroquine (HCQ), in autoimmune diseases. The reported frequency of retinopathy, however, is much lower for HCQ than for CQ (less than 0.08% versus 1-2%). To test whether the difference in toxicity between the two lysosomotropic drugs is related to… CONTINUE READING